Science and medicine


09-01-2007 12:38 - Zdroj: david-daniel.blog.cz
Science & Medicine | Phase I Clinical Trial of Experimental Gene Therapy To Treat HIV Shows Encouraging Results, Researchers Say[Nov 08, 2006]The results of a Phase I clinical trial of an experimental gene therapy aimed at treating HIV indicate that the therapy is safe and effective and also might sustain viral loads, according to a study published on Monday in the online edition of the Proceedings of the National Academy of Sciences, the AP/Washington Post reports. According to the researchers, the Phase I trial results are encouraging enough for them to proceed with a more extensive Phase II trial, the AP/Post reports (Schmid, Washington Post, 11/6). Carl June and Bruce Levine of the University of Pennsylvania's Abramson Family Cancer Research Institute and colleagues from the Gaithersburg, Md.-based Virxsys -- which is helping to develop the gene therapy treatment and fund the study -- over a nine-month period conducted the study among five HIV-positive people who had developed drug resistance, BBC News reports. The study participants each received a single infusion of their immune system's CD4+ T cells. The infusions contained about 10 billion T cells, which is between 2% and 10% of the total number of T cells in an average person's immune system. The T cells were genetically modified to carry a manipulated version of HIV. This modified version of the virus carried an antisense RNA molecule, which manipulates the process of reading genetic data so that the method HIV uses to reproduce itself inside infected cells is disrupted, according to BBC News (BBC News, 11/6). The introduction of the RNA molecule in laboratory settings also has been shown to be an effective HIV therapy in treatment-naive cells, according to June. The researchers found that the treatment stabilized or decreased viral loads in study participants over the course of the trial. In addition, T-cell counts remained steady or increased in four of the five participants, according to the study. ... - Pokračovat...
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